![]() ![]() In vivo Ca 2+ imaging in freely moving mice revealed that a subset of vCA1 neurons is activated by the presence of familiar mice during social interactions however, how the activities of these social neurons are organized and maintained at the fine temporal resolution necessary for effective memory encoding and recall remains unknown. In particular, the ventral CA1 sub-region of the hippocampus (vCA1) contains neurons that respond to other individuals but not to inanimate objects and has been identified as a key locus for social memory storage. Several brain regions have been identified as being associated with the experience-dependent encoding of social characteristics in rodents. The ability to recognize and memorize familiar conspecifics is crucial for animals that engage in social interactions. These results suggest that SPW-R-mediated sequential reactivation of neuronal ensembles is a canonical mechanism for coordinating hippocampus-dependent social memories and its disruption underlie the pathophysiology of social memory defects associated with ASD. In ASD model Shank3 knockout mice, the proportion of social memory neurons was reduced, and neuronal ensemble spike sequences during SPW-Rs were disrupted, which correlated with impaired discriminatory social behavior. Spike sequences of these social replays reflected the temporal orders of neuronal activities within theta cycles during social experiences. ![]() Here we show that vCA1 social memory neurons, characterized by enhanced activity in response to memorized individuals, were preferentially reactivated during sharp-wave ripples (SPW-Rs). Although hippocampal ventral CA1 (vCA1) neurons are known to store social memories, how their activities are coordinated remains unclear. The ability to remember conspecifics is critical for adaptive cognitive functioning and social communication, and impairments of this ability are hallmarks of autism spectrum disorders (ASDs). ![]()
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